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Waters Neutrals Quality Control Reference Material (QCRM) is a mixture of three neutral compounds that are an ideal system reference standard. Due to the use of neutral compounds the QCRM is unaffected by mobile phase pH and compatible with buffered and non-buffered mobile phases at both high and low pH. This makes Waters QCRM universally applicable on many different HPLC and UHPLC systems with different column chemistries and different mobile phases. By using the reference to benchmark system performance, data integrity can be monitored and assured. QC Reference Materials are available for Neutrals, Reversed-Phase and LCMS as well as a Preparative Chromatography Standard.