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To keep HPLC and UHPLC systems free of contaminants that can damage the analytical column or even the entire system, the highest purity for all solutions that come into direct contact with the plant is necessary. In addition to regular maintenance of the system it is recommended to use an inline-filter to protect the column and the plant. The housing of the inline-filter is made of PEEK or stainless steel with a frit in the interior and standard fittings at both ends. There are inline-filters, which are completely replaced if necessary, or a variant in which only the frit must be replaced.

We carry numerous inline-filters of well-known manufacturers such as Agilent Technologies, Vici Jour and Merck. If you have any problems when choosing a product, feel free to contact us.

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HPLC Inline-Filter

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  1. Upchurch Scientific

    Precolumn Filter, PEEK, 2µm, 1pc/PAK

    €79.88
    SKU: UPA-355
    In Stock
  2. Upchurch Scientific

    SemiPrep Inline Filter Assembly, 10µm, 1pc/PAK

    €143.53
    SKU: UPA-411
    In Stock
  3. Upchurch Scientific

    Inline Filter Assembly, 0.5µm, 1pc/PAK

    €38.07
    SKU: UPA-431
    In Stock
  4. Upchurch Scientific

    VHP Replacement Filter, 0.2µm, 1 pc/PAK

    €31.83
    SKU: UPVHP-506
    In Stock
  5. Waters

    Filter (Last Drop)W, 2µm SS

    €95.00
    SKU: WTPSL901290
    In Stock
  6. Waters

    Filter (Last Drop)W, 10µm SS

    €95.00
    SKU: WTPSL901291
    In Stock
  7. Waters

    Filter (Last Drop)W, 2µm PAT

    €95.00
    SKU: WTPSL901292
    In Stock
  8. Waters

    Filter (Last Drop)W, 5µm PAT

    €95.00
    SKU: WTPSL901294
    In Stock
  9. Waters

    In-Line precolumn Filter kit

    €340.00
    SKU: WTWAT084560
    In Stock
  10. Waters

    Precolumn Filter Insert Assembly

    €23.00
    SKU: WTWAT088084
  11. Upchurch Scientific

    Precolumn Filter Assy 2µm, 1pc/PAK

    €77.37
    SKU: UPA-315
  12. Upchurch Scientific

    SemiPrep Inline Filter Assembly, 2µm, 1pc/PAK

    €143.53
    SKU: UPA-410
  13. Upchurch Scientific

    VHP Inline Filter, 0.2µm, 1pc/PAK

    €398.20
    SKU: UPVHP-505
  14. Agilent Technologies

    Inline Filter, stainless steel, 0,2 µm, 4,6 mm, for RRLC, con. capill.

    Regular Price: €276.00

    Special Price €267.72

    SKU: AG5067-1553
  15. Supelco

    Inline Filter, PEEK filter, with fittings

    €114.00
    SKU: SU502707
  16. Supelco

    Inline Filter, stainless steel, 0,2 µm

    €357.00
    SKU: SU52246-U
  17. Supelco

    Inline Filter, 2 µm, high pressure

    €43.00
    SKU: SU55078
  18. Supelco

    Inline Filter, 0,5 µm, high pressure

    €43.00
    SKU: SU55079
  19. Supelco

    Inline Filter, check valve

    €118.00
    SKU: SU55085-U
  20. Upchurch Scientific

    Precolumn Filter, 0.5µm, 1,3µl swept volume, 1pc/PAK

    €78.01
    SKU: UPA-316
  21. Upchurch Scientific

    Precolumn Filter, 0.5µm, 0, 84µl swept volume, 1pc/PAK

    €99.23
    SKU: UPA-318
  22. Upchurch Scientific

    SemiPrep Filter Assembly, 10 µm, 1pc/PAK

    €124.80
    SKU: UPA-330
  23. Upchurch Scientific

    Precolumn Filter, PEEK, 0.5µm, 1pc/PAK

    €79.88
    SKU: UPA-356
  24. Upchurch Scientific

    SemiPrep Filter Assembly, 10µm, 1pc/PAK

    €224.67
    SKU: UPA-360
  25. Upchurch Scientific

    Low Pressure Inline Filter, 2 µm, for 1/16'' OD

    €34.31
    SKU: UPA-415
  26. Upchurch Scientific

    Low Pressure Inline Filter, 2 µm, for 1/8'' OD, 1pc/PAK

    €34.31
    SKU: UPA-416
  27. Upchurch Scientific

    Inline Filter Assembly, 2µm, 1pc/PAK

    €43.05
    SKU: UPA-430
  28. Upchurch Scientific

    SemiPrep Filter, 5µm, for 3/16'' OD, 1pc/PAK

    €143.53
    SKU: UPA-510
  29. Upchurch Scientific

    NanoFilter Capsule, 1µm, Titaniumfrit, 2 pc/PAK

    €108.58
    SKU: UPM-126
  30. Upchurch Scientific

    Precolumn MicroFilter Assembly, 1pc/PAK

    €149.77
    SKU: UPM-510
  31. Upchurch Scientific

    Mini MicroFilter Assembly, 1µm, 5 capsules, 1pc/PAK

    €255.87
    SKU: UPM-533
  32. Upchurch Scientific

    Precolumn MicroFilter, 0.5µm, with 5 SSfrits, 1pc/PAK

    €149.77
    SKU: UPM-550
  33. Upchurch Scientific

    Stainless Steel Conductive Capsule 1µm, 2 pc/PAK

    €180.97
    SKU: UPM-128
  34. Agilent Technologies

    Inline Filter, stainless steel, 0,2 µm, 2,1 mm, for RRLC, con. capill.

    Regular Price: €216.00

    Special Price €209.52

    SKU: AG5067-1551
  35. Agilent Technologies

    Inline Filter, stainless steel, LC-2010/20AD/AB/AT SHM

    Regular Price: €114.00

    Special Price €110.58

    SKU: AG8001-0808
  36. Upchurch Scientific

    Inline Filter, metal free, 2µm, for 1/16'' OD, 1pc/PAK

    €28.68
    SKU: UPA-424
  37. Upchurch Scientific

    Inline Filter, metal free, 10µm, for 1/16'' OD, 1pc/PAK

    €26.21
    SKU: UPA-425
  38. Upchurch Scientific

    Inline MicroFilter Assembly, with 5 fittings, 1pc/PAK

    €131.04
    SKU: UPM-520
  39. Upchurch Scientific

    Inline MicroFilter Kit, PEEK, 0.5µm, for 1/32'' OD

    €143.53
    SKU: UPM-525
  40. PerkinElmer

    Inlet HPLC Filter, 2 µm

    €50.00
    SKU: PE09923405
  41. Upchurch Scientific

    Precolumn MicroFilter Assembly 0.5µm, 5 SS frits, 1pc/PAK

    €149.77
    SKU: UPM-500
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HPLC inline filters for your laboratory

Use of inline filters in chromatography

Impurities can not only get into the system from outside but also from the system itself. The main sources are mainly the piston seals the pump or the rotor seal the injection valve, which can produce abrasion with increasing operating time. This abrasion can lead to deposits / blockage on the stationary phase or in the HPLC system.

In addition to regular maintenance of the system it is recommended to use an inline filter to protect the column and the plant. But what is the inline filter and why makes its use a lot of sense? And what is important in choosing the right inline filter?

The in-line filter can be positioned at various locations of the HPLC system. If the inline filter is installed between the pump and the injector, particles and impurities are removed from the eluent. Likewise, abrasion of the piston seal is intercepted, so that the rotor seal of the injection valve is protected from abrasion and fine particles. When positioning directly in front of the column after the injection valve and contaminants from the sample are removed and abrasion of the rotor seals.

In addition to the inline filter it is usually recommended to use a guard column. Molecules that can be attached irreversibly to the main column can not be retained with the inline filter. Inline filters are available in various designs. In addition to housing, which is either made of PEEK or stainless steel can also choose between different fittings. These depend on the place where the inline filter should be installed. Thus, there are also housing, which are provided for the direct connection to the analytical column.

Accessories for the inline filters: frits

The frits for the inline filters are usually made of stainless steel and are often surrounded by a ring of PEEK. This serves as a seal ring, while minimizing the dead volume of the inline filter, so that no negative effects such as peak broadening can be expected. Stainless steel frits can be used for the current analysis. For applications requiring high corrosion resistance and biocompatibility, frits made of other materials such as Titanium or polymers are available. Also, the surrounding ring can be made of other materials, such as of PTFE. The user then has the possibility to choose a matching inline filter depending on the sample to be analyzed and the chemical properties of the mobile phase.

Typical pore sizes of the frits are 2 and 0.5 microns. When using columns with a particle size of <5 micron, frits with 0.5 microns should be used. For UHPLC systems and columns with particle sizes below 2 microns using frits with a pore size of 0.2 microns is recommended. The maximum pressure is 1000 bar and they have a low dead volume.

In the long term, the use of inline filters in the HPLC analysis has many advantages and saves money. Maintenance costs will be reduced and the facility and the separation column with usage of the inline filter will guarantee an extended service life.