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To keep HPLC and UHPLC systems free of contaminants that can damage the analytical column or even the entire system, the highest purity for all solutions that come into direct contact with the plant is necessary. In addition to regular maintenance of the system it is recommended to use an inline-filter to protect the column and the plant. The housing of the inline-filter is made of PEEK or stainless steel with a frit in the interior and standard fittings at both ends. There are inline-filters, which are completely replaced if necessary, or a variant in which only the frit must be replaced.

We carry numerous inline-filters of well-known manufacturers such as Agilent Technologies, Vici Jour and Merck. If you have any problems when choosing a product, feel free to contact us.

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HPLC Inline-Filter

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  1. Upchurch Scientific

    Inline MicroFilter Assembly 1µm, Stainless Steel- 5/pk Single

    SKU: UPM-135-1
  2. Upchurch Scientific

    Stainless Steel Inline Solvent Filter w/20µm Frit

    SKU: UPA-313
  3. Upchurch Scientific

    Inline MicroFilter Assembly 5 Fittings

    SKU: UPM-520
  4. Upchurch Scientific

    Inline VHP Filter 0.2µm

    SKU: UPVHP-505
  5. Merck

    Inline Filter, filter cartridge

    SKU: MC1511930001
  6. Supelco

    Inline Filter, PEEK filter, with fittings

    SKU: SU502707
  7. Supelco

    Inline Filter, stainless steel, 0,2 µm

    SKU: SU52246-U
  8. Supelco

    Inline Filter, 2 µm, high pressure

    SKU: SU55078
  9. Supelco

    Inline Filter, 0,5 µm, high pressure

    SKU: SU55079
  10. Supelco

    Inline Filter, check valve

    SKU: SU55085-U
  11. Waters

    In-Line precolumn Filter kit

    SKU: WTWAT084560
  12. Upchurch Scientific

    Inline Filter, solvent filter, female end

    SKU: UPA-314-01
  13. Agilent Technologies

    Inline Filter, stainless steel, LC-2010/20AD/AB/AT SHM

    SKU: AG8001-0808
  14. Upchurch Scientific

    Stainless Steel Inline Solvent Filter, 2µm

    SKU: UPA-314
  15. Upchurch Scientific

    Inline Filter Metal Free 2µm, for 1/16'' OD

    SKU: UPA-424
  16. Upchurch Scientific

    Inline Filter Metal Free 10µm, for 1/16'' OD

    SKU: UPA-425
  17. Upchurch Scientific

    Inline MicroFilter Kit PEEK 0.5µm

    SKU: UPM-525
  18. Waters

    Solvent Filter A309

    SKU: WTPSL613457
  19. Waters

    Solvent Inlet Filter, 10 µm, 1/8 OD

    SKU: WTPSL613578
  20. Waters

    Filter (Last Drop)W, 2µm SS

    SKU: WTPSL901290
  21. Waters

    Filter (Last Drop)W, 10µm SS

    SKU: WTPSL901291
  22. Waters

    Filter (Last Drop)W, 2µm PAT

    SKU: WTPSL901292
  23. Waters

    Filter (Last Drop)W, 5µm PAT

    SKU: WTPSL901294
  24. QLA

    Inline Filter, housing assembly

  25. SGE


    Regular Price: €32.64

    Special Price €32.00

    SKU: SG202009
  26. Agilent Technologies

    Inline Filter, 2 µm, low dispersion

    SKU: AG01090-68702
  27. Agilent Technologies

    Inline Filter, Universal-Kit: 2 frits, frit holder, connection capill.

    SKU: AG01090-68703
  28. Agilent Technologies

    Inline Filter, 0,5 µm, u-LC

    SKU: AG5064-8273
  29. Agilent Technologies

    Inline Filter, glass, 10 µm, kit

    SKU: AG5065-4500
  30. Agilent Technologies

    In-line SS filter for G1311A

    SKU: AGG1311-60006
  31. Upchurch Scientific

    Inline Filter, body .006in thru

    SKU: UPM-520-01
  32. Upchurch Scientific

    Inline Filter, solvent filter, male end

    SKU: UPA-314-02
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HPLC inline filters for your laboratory

Use of inline filters in chromatography

Impurities can not only get into the system from outside but also from the system itself. The main sources are mainly the piston seals the pump or the rotor seal the injection valve, which can produce abrasion with increasing operating time. This abrasion can lead to deposits / blockage on the stationary phase or in the HPLC system.

In addition to regular maintenance of the system it is recommended to use an inline filter to protect the column and the plant. But what is the inline filter and why makes its use a lot of sense? And what is important in choosing the right inline filter?

The in-line filter can be positioned at various locations of the HPLC system. If the inline filter is installed between the pump and the injector, particles and impurities are removed from the eluent. Likewise, abrasion of the piston seal is intercepted, so that the rotor seal of the injection valve is protected from abrasion and fine particles. When positioning directly in front of the column after the injection valve and contaminants from the sample are removed and abrasion of the rotor seals.

In addition to the inline filter it is usually recommended to use a guard column. Molecules that can be attached irreversibly to the main column can not be retained with the inline filter. Inline filters are available in various designs. In addition to housing, which is either made of PEEK or stainless steel can also choose between different fittings. These depend on the place where the inline filter should be installed. Thus, there are also housing, which are provided for the direct connection to the analytical column.

Accessories for the inline filters: frits

The frits for the inline filters are usually made of stainless steel and are often surrounded by a ring of PEEK. This serves as a seal ring, while minimizing the dead volume of the inline filter, so that no negative effects such as peak broadening can be expected. Stainless steel frits can be used for the current analysis. For applications requiring high corrosion resistance and biocompatibility, frits made of other materials such as Titanium or polymers are available. Also, the surrounding ring can be made of other materials, such as of PTFE. The user then has the possibility to choose a matching inline filter depending on the sample to be analyzed and the chemical properties of the mobile phase.

Typical pore sizes of the frits are 2 and 0.5 microns. When using columns with a particle size of <5 micron, frits with 0.5 microns should be used. For UHPLC systems and columns with particle sizes below 2 microns using frits with a pore size of 0.2 microns is recommended. The maximum pressure is 1000 bar and they have a low dead volume.

In the long term, the use of inline filters in the HPLC analysis has many advantages and saves money. Maintenance costs will be reduced and the facility and the separation column with usage of the inline filter will guarantee an extended service life.