HPLC Inline-Filter

To keep HPLC and UHPLC systems free of contaminants that can damage the analytical column or even the entire system, the highest purity for all solutions that come into direct contact with the plant is necessary. In addition to regular maintenance of the system it is recommended to use an inline-filter to protect the column and the plant. The housing of the inline-filter is made of PEEK or stainless steel with a frit in the interior and standard fittings at both ends. There are inline-filters, which are completely replaced if necessary, or a variant in which only the frit must be replaced.

We carry numerous inline-filters of well-known manufacturers such as Agilent Technologies, Vici Jour and Merck. If you have any problems when choosing a product, feel free to contact us.

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Product Image of Precolumn Filter Male End, 1pc/PAK
Precolumn Filter Male End, 1pc/PAK
Item number: UPA-315-02
Brand: Upchurch Scientific
€62.08
Product Image of Precolumn Filter Female End, 1pc/PAK
Precolumn Filter Female End, 1pc/PAK
Item number: UPA-315-01
Brand: Upchurch Scientific
€49.85
Product Image of Inline Filter, check valve
Inline Filter, check valve
Item number: SU55085-U
Brand: Supelco
€187.43
Product Image of Inline Filter, 0,5 µm, high pressure
Inline Filter, 0,5 µm, high pressure
Item number: SU55079
Brand: Supelco
€71.09
Product Image of Inline Filter, 2 µm, high pressure
Inline Filter, 2 µm, high pressure
Item number: SU55078
Brand: Supelco
€41.23
Product Image of Inline Filter, PEEK filter, with fittings
Inline Filter, PEEK filter, with fittings
Item number: SU502707
Brand: Supelco
€181.57
Product Image of Inline Filter, 2 µm, High Pressure Cup Type
Inline Filter, 2 µm, High Pressure Cup Type
Item number: RE25041
Brand: Restek
€81.00
Product Image of Inline Filter, 0,5 µm, 1/16'', High Pressure Cup Type
Inline Filter, 0,5 µm, 1/16'', High Pressure Cup Type
Item number: RE25000
Brand: Restek
€259.20
Product Image of Inline Filter, Ultraline Replacement Filter
Inline Filter, Ultraline Replacement Filter
Item number: RE24994
Brand: Restek
€137.13
Product Image of Inline Filter, UltraLine, assembly, for UHPLC
Inline Filter, UltraLine, assembly, for UHPLC
Item number: RE24993
Brand: Restek
€287.87
Product Image of Inline Filter, housing assembly
Inline Filter, housing assembly
Item number: QLFILASY-DK
Brand: QLA
€86.76
Product Image of Inline Filter, filter cartridge
Inline Filter, filter cartridge
Item number: MC1511930001
Brand: Merck
€175.10 €206.00
Product Image of Inline Filter, ADS, 5 gaskets, PEEK Filter, for LiChroCART
Inline Filter, ADS, 5 gaskets, PEEK Filter, for LiChroCART
Item number: MC1511920001
Brand: Merck
€217.60 €272.00
Product Image of HPLC Pre Column Filter ACE, 0.5 µm
HPLC Pre Column Filter ACE, 0.5 µm
Item number: ACACE-CS201
Brand: ACE
€41.20
Product Image of Replacement Precolumn Filter 0.5 µm for 1/16'' o.d., stainless steel (600 bar), 5 pc/PAK
Replacement Precolumn Filter 0.5 µm for 1/16'' o.d., stainless steel (600 bar), 5 pc/PAK
Item number: YMXRPRCS35
Brand: YMC
€210.00
Product Image of Precolumn Filter, 0.5 µm, for 1/16'' OD + Holder, stainless steel (600 bar)
Precolumn Filter, 0.5 µm, for 1/16'' OD + Holder, stainless steel (600 bar)
Item number: YMXRPRCS03
Brand: YMC
€288.00
Product Image of ACE UHPLC Pre-Column Filter Waters Acquity Compatible (10 Pack)
ACE UHPLC Pre-Column Filter Waters Acquity Compatible (10 Pack)
Item number: ACEXL-PCF10/ACQ
Brand: ACE
€740.00
Product Image of ACE UHPLC Pre-Column Filter (10 Pack)
ACE UHPLC Pre-Column Filter (10 Pack)
Item number: ACEXL-PCF10
Brand: ACE
€707.00
Product Image of ACE UHPLC Pre-Column Filter Waters Acquity Compatible (5 Pack)
ACE UHPLC Pre-Column Filter Waters Acquity Compatible (5 Pack)
Item number: ACEXL-PCF05/ACQ
Brand: ACE
€379.00
Product Image of ACE UHPLC Pre-Column Filter (5 Pack)
ACE UHPLC Pre-Column Filter (5 Pack)
Item number: ACEXL-PCF05
Brand: ACE
€369.00
Product Image of ACE UHPLC Pre-Column Filter Waters Acquity Compatible
ACE UHPLC Pre-Column Filter Waters Acquity Compatible
Item number: ACEXL-PCF01/ACQ
Brand: ACE
€83.80
Product Image of ACE UHPLC Pre-Column Filter
ACE UHPLC Pre-Column Filter
Item number: ACEXL-PCF01
Brand: ACE
€80.20
Product Image of ACE Microbore Hplc Pre-Column Filter (10 Pack)
ACE Microbore Hplc Pre-Column Filter (10 Pack)
Item number: ACACE-HP210
Brand: ACE
€369.00
Product Image of ACE Microbore Hplc Pre-Column Filter
ACE Microbore Hplc Pre-Column Filter
Item number: ACACE-HP205
Brand: ACE
€203.00
Product Image of ACE Analytical Hplc 2.0µm Pre-Column Filter (10 Pack)
ACE Analytical Hplc 2.0µm Pre-Column Filter (10 Pack)
Item number: ACACE-CS310
Brand: ACE
€286.00
Product Image of ACE Analytical Hplc 2.0µm Pre-Column Filter (5 Pack)
ACE Analytical Hplc 2.0µm Pre-Column Filter (5 Pack)
Item number: ACACE-CS305
Brand: ACE
€154.00
Product Image of ACE Analytical Hplc 0.5µm Pre-Column Filter (10 Pack)
ACE Analytical Hplc 0.5µm Pre-Column Filter (10 Pack)
Item number: ACACE-CS210
Brand: ACE
€286.00
Product Image of ACE Analytical Hplc 0.5µm Pre-Column Filter (5 Pack)
ACE Analytical Hplc 0.5µm Pre-Column Filter (5 Pack)
Item number: ACACE-CS205
Brand: ACE
€154.00
Product Image of Replacement Precolumn Filter 2 µm for 1/16'' o.d., PEEK (350 bar), 5 pc/PAK
Replacement Precolumn Filter 2 µm for 1/16'' o.d., PEEK (350 bar), 5 pc/PAK
Item number: YMXRPRCP25
Brand: YMC
€210.00
Product Image of Precolumn Filter, 2 µm, for 1/16'' OD + Holder, PEEK (350 bar)
Precolumn Filter, 2 µm, for 1/16'' OD + Holder, PEEK (350 bar)
Item number: YMXRPRCP02
Brand: YMC
€288.00
Product Image of HPLC Guard Column GPC HK-G, 1 Holder + 1 Filter
HPLC Guard Column GPC HK-G, 1 Holder + 1 Filter
Item number: SDF6700200
Brand: Shodex
€560.00
Product Image of HPLC Guard Column GPC HK-G filter, 3 Filter
HPLC Guard Column GPC HK-G filter, 3 Filter
Item number: SDF6700100
Brand: Shodex
€420.00
Product Image of Filter Assay 3 mm, 3.9 mm x 4.6 mm, 2 µm
Filter Assay 3 mm, 3.9 mm x 4.6 mm, 2 µm
Item number: WT600000179
Brand: Waters
€85.00
Product Image of Inline-Filter, PEEK, female Connector, complete, Titanium Frit 0,181'', PEEK-encased, 2 µm, minimum order amount 11 pieces
Inline-Filter, PEEK, female Connector, complete, Titanium Frit 0,181'', PEEK-encased, 2 µm, minimum order amount 11 pieces
Item number: MV49681-120
Brand: Microsolv
€80.54
Product Image of Inline-Filter, PEEK, female Connector, complete, Titanium Frit 0,181'', PEEK-encased, 0,5 µm, minimum order amount 11 pieces
Inline-Filter, PEEK, female Connector, complete, Titanium Frit 0,181'', PEEK-encased, 0,5 µm, minimum order amount 11 pieces
Item number: MV49680-105
Brand: Microsolv
€80.54
Product Image of Inline-Filter, PEEK, female Connector, complete, PEEK Frit 0,181'', PEEK-encased, 2 µm, minimum order amount 11 pieces
Inline-Filter, PEEK, female Connector, complete, PEEK Frit 0,181'', PEEK-encased, 2 µm, minimum order amount 11 pieces
Item number: MV49681-020
Brand: Microsolv
€91.05
Product Image of Inline-Filter, PEEK, male Connector, complete, PEEK Frit 0,181'', PEEK-encased, 2 µm, minimum order amount 11 pieces
Inline-Filter, PEEK, male Connector, complete, PEEK Frit 0,181'', PEEK-encased, 2 µm, minimum order amount 11 pieces
Item number: MV49680-020
Brand: Microsolv
€80.54
Product Image of Inline MicroFilter Assembly, SS, 1µm, with 5 M130 fittings, 1pc/PAK
Inline MicroFilter Assembly, SS, 1µm, with 5 M130 fittings, 1pc/PAK
Item number: UPM-135-1
Brand: Upchurch Scientific
€154.78
Product Image of Inline Filter for Guard Column, SS, 2 µm, 10 pc/PAK
Inline Filter for Guard Column, SS, 2 µm, 10 pc/PAK
Item number: MV49650-020
Brand: Applied Research Europe
€201.35
Product Image of Inline Filter for Guard Column, SS, 0.5 µm, 10 pc/PAK
Inline Filter for Guard Column, SS, 0.5 µm, 10 pc/PAK
Item number: MV49650-005
Brand: Applied Research Europe
€201.35
Product Image of Refill Frits, SS, for 102020-21200, 5 pc/PAK
Refill Frits, SS, for 102020-21200, 5 pc/PAK
Item number: SP102020-00001
Brand: Sepax
€346.29
Product Image of Precolumn Filter, SS, 2 µm frit for prep columns with 21.2 mm ID and above
Precolumn Filter, SS, 2 µm frit for prep columns with 21.2 mm ID and above
Item number: SP102020-21200
Brand: Sepax
€592.00
Product Image of Precolumn Filter, PEEK, with 0.5 µm SS Frit
Precolumn Filter, PEEK, with 0.5 µm SS Frit
Item number: SP102000-P346
Brand: Sepax
€164.57
Product Image of Refill Frit for HPLC Guard Column Filter, SS, 0.5 µm, 5 pc/PAK
Refill Frit for HPLC Guard Column Filter, SS, 0.5 µm, 5 pc/PAK
Item number: SP102001-P346
Brand: Sepax
€197.71
Product Image of Inline Filter, SS, LC-2010/20AD/AB/AT SHM
Inline Filter, SS, LC-2010/20AD/AB/AT SHM
Item number: AG8001-0808
Brand: Agilent Technologies
€166.00
Product Image of Frit, Titan, 4,6 mm ID, for 5 µm Bio Pump filter, 2 pc/PAK
Frit, Titan, 4,6 mm ID, for 5 µm Bio Pump filter, 2 pc/PAK
Item number: AG5320-0048
Brand: Agilent Technologies
€167.00
Product Image of Frit, Titanium, 2 mm ID, for 0,3 µm Bio Inline-Filter, 5 pc/PAK
Frit, Titanium, 2 mm ID, for 0,3 µm Bio Inline-Filter, 5 pc/PAK
Item number: AG5320-0022
Brand: Agilent Technologies
€580.00
Product Image of Quick Change Inline Filter Assembly, SS, 0.5 µm, 4.6 mm ID, 1300 bar, for UHPLC
Quick Change Inline Filter Assembly, SS, 0.5 µm, 4.6 mm ID, 1300 bar, for UHPLC
Item number: AG5067-1603
Brand: Agilent Technologies
€518.00
Product Image of Quick Change Inline Filter Assembly, SS, 0.5 µm, 4.6 mm ID, 1300 bar, for HPLC
Quick Change Inline Filter Assembly, SS, 0.5 µm, 4.6 mm ID, 1300 bar, for HPLC
Item number: AG5067-1602
Brand: Agilent Technologies
€518.00
Product Image of Bio Inline-Filter-Upgrade-Kit
Bio Inline-Filter-Upgrade-Kit
Item number: AGG7131-68000
Brand: Agilent Technologies
€726.00

Use of inline filters in chromatography

Impurities can not only get into the system from outside but also from the system itself. The main sources are mainly the piston seals the pump or the rotor seal the injection valve, which can produce abrasion with increasing operating time. This abrasion can lead to deposits / blockage on the stationary phase or in the HPLC system.

In addition to regular maintenance of the system it is recommended to use an inline filter to protect the column and the plant. But what is the inline filter and why makes its use a lot of sense? And what is important in choosing the right inline filter?

The in-line filter can be positioned at various locations of the HPLC system. If the inline filter is installed between the pump and the injector, particles and impurities are removed from the eluent. Likewise, abrasion of the piston seal is intercepted, so that the rotor seal of the injection valve is protected from abrasion and fine particles. When positioning directly in front of the column after the injection valve and contaminants from the sample are removed and abrasion of the rotor seals.

In addition to the inline filter it is usually recommended to use a guard column. Molecules that can be attached irreversibly to the main column can not be retained with the inline filter. Inline filters are available in various designs. In addition to housing, which is either made of PEEK or stainless steel can also choose between different fittings. These depend on the place where the inline filter should be installed. Thus, there are also housing, which are provided for the direct connection to the analytical column.

Accessories for the inline filters: frits

The frits for the inline filters are usually made of stainless steel and are often surrounded by a ring of PEEK. This serves as a seal ring, while minimizing the dead volume of the inline filter, so that no negative effects such as peak broadening can be expected. Stainless steel frits can be used for the current analysis. For applications requiring high corrosion resistance and biocompatibility, frits made of other materials such as Titanium or polymers are available. Also, the surrounding ring can be made of other materials, such as of PTFE. The user then has the possibility to choose a matching inline filter depending on the sample to be analyzed and the chemical properties of the mobile phase.

Typical pore sizes of the frits are 2 and 0.5 microns. When using columns with a particle size of <5 micron, frits with 0.5 microns should be used. For UHPLC systems and columns with particle sizes below 2 microns using frits with a pore size of 0.2 microns is recommended. The maximum pressure is 1000 bar and they have a low dead volume.

In the long term, the use of inline filters in the HPLC analysis has many advantages and saves money. Maintenance costs will be reduced and the facility and the separation column with usage of the inline filter will guarantee an extended service life.