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Using rotating baskets for tablet dissolution was the first official method and was adopted in 1970. This method is now known as Apparatus 1 or Method 1. The metallic drive shaft of the apparatus is connected to the cylindrical basket. The basket is positioned inside a vessel made of glass or other inert, transparent material. To keep the vessel contents at a constant temperature, they are placed inside a water bath or heating jacket. The rotating basket smoothly stirs the solution in the vessel. Dissolution baskets should be perfectly round, not deformed, with the correct and verified mesh size. The USP Method 1 requires a 40-mesh screen unless otherwise specified in the monograph. Other meshes can be used to solve individual problems.

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Dissolution Baskets and Shafts

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  1. QLA

    Suppository Basket for Caleva, Plastic

    €131.25
    SKU: QLBSKSUP-CA
  2. QLA

    Suppository Basket for Erweka, Plastic

    €131.25
    SKU: QLBSKSUP-EW
  3. QLA

    Suppository Basket for Hanson, Plastic

    €131.25
    SKU: QLBSKSUP-HR
  4. QLA

    Suppository Basket for Pharmatest, Plastic

    €131.25
    SKU: QLBSKSUP-PT
  5. QLA

    Suppository Basket for Sotax, Plastic

    €131.25
    SKU: QLBSKSUP-ST
  6. QLA

    16 Position Paddle/Basket Shaft Holder

    €275.10
    SKU: QLPADHLD-16A
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Mesh Openings

The clogging of the mesh openings by particles or excipients or the random release of particles through the mesh to the bottom of the vessel are one of the biggest problems associated with the basket method. Suppository Baskets are from plastic, these baskets have vertical slots instead of mesh. This facilitates dissolution and prevents blocking and/or clogging of the mesh opening, particularly when oil-based suppositories are used. Sintered Mesh stainless steel baskets have welded joins at all the wire overlaps and adds considerable strength and longevity to the basket. Sintering is a strengthening process that compresses and heats the mesh under high pressures and temperatures. Baskets with a wide variety of mesh openings are available and if the disaggregated particle size is consistent, a variation of mesh size may solve some difficult dissolution problems.

Care and maintenance

The mesh of the dissolution baskets is easily bent and so they should only be handled by the rim. This also prevents oily deposits from fingers left on the mesh. Care should be exercised to ensure that baskets are clean prior to use and to ensure there is no contamination between tests. Correct storage of the baskets can extend their life. Baskets can easily be stored in the supplier’s case or using a specially designed basket holder.

Basket Shafts

As a part of Apparatus 1 the basket shaft is a metallic drive shaft which is attached to the cylindrical basket. They are available in two different versions, the spring-clip style and the O-ring style:

  • Spring Clips: the standard version of the dissolution basket is created so that the basket shaft is attached to it through the spring clips. As time passes, these clips can bend or corrode which can lead to excessive wobble of the dissolution basket on the shaft.
  • O-Ring: the clipless basket is attached to the shaft using an O-ring instead of the spring clips. While it can be argued that this design reduces wobble and is easier to use, the USP still specifies the use of clips and proof of equivalence may be required if a clipless alternative is to be used.

Care and Maintenance

Proper storage of the shafts is extremely important - a bent or corroded shaft fails to comply with USP regulations, so it is crucial not to store shafts on a table or loose in a drawer where damage or corrosion can occur. The right way to store is e.g. in a basket shaft or paddle holder as it can prevent occuring damage.