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The clogging of the mesh openings by particles or excipients or the random release of particles through the mesh to the bottom of the vessel are one of the biggest problems associated with the basket method. Suppository Baskets are from plastic, these baskets have vertical slots instead of mesh. This facilitates dissolution and prevents blocking and/or clogging of the mesh opening, particularly when oil-based suppositories are used. Sintered Mesh stainless steel baskets have welded joins at all the wire overlaps and adds considerable strength and longevity to the basket. Sintering is a strengthening process that compresses and heats the mesh under high pressures and temperatures. Baskets with a wide variety of mesh openings are available and if the disaggregated particle size is consistent, a variation of mesh size may solve some difficult dissolution problems.
The mesh of the dissolution baskets is easily bent and so they should only be handled by the rim. This also prevents oily deposits from fingers left on the mesh. Care should be exercised to ensure that baskets are clean prior to use and to ensure there is no contamination between tests. Correct storage of the baskets can extend their life. Baskets can easily be stored in the supplier’s case or using a specially designed basket holder.
As a part of Apparatus 1 the basket shaft is a metallic drive shaft which is attached to the cylindrical basket. They are available in two different versions, the spring-clip style and the O-ring style:
Proper storage of the shafts is extremely important - a bent or corroded shaft fails to comply with USP regulations, so it is crucial not to store shafts on a table or loose in a drawer where damage or corrosion can occur. The right way to store is e.g. in a basket shaft or paddle holder as it can prevent occuring damage.