Highly polar and hydrophilic analytes that are difficult to analyze with conventional C18 columns can be retained with Thermo Scientific™ Hypersil GOLD™ PEI HILIC LC columns for hydrophilic interaction chromatography. These columns enable straightforward separations without sample derivatization or ion-pairing reagents. The columns feature excellent peak shape and selectivity and offer improved sensitivity in MS detection. With particle sizes of 1.9, 3 and 5 µm, Hypersil GOLD PEI-HILIC columns are ideal for applications in drug development as well as in food and environmental analysis.