LiChrospher® 100 CN possess both polar and hydrophobic properties, and combines weak hydrophobic interactions with polar interactions. This enables successful HPLC separations of complex samples. The sorbent can be used as a less polar alternative to LiChrospher® Si 60 in normal-phase applications, or as a less hydrophobic alternative to LiChrospher® RP-8 in reversed-phase applications. This highly versatile sorbent is also suitable for selective charged interactions.