Flash chromatography is a liquid chromatographic separation method used for many years in chemical and organic laboratories, especially for fast preparative purposes. In literature it is described as a "quick-and-dirty" method for the purification or isolation of substances. Compared to preparative HPLC separation, this separation method is the more time-efficient and economical approach. It can either be carried out manually with little effort or automated with appropriate equipment. In contrast to HPLC, in flash chromatography compounds are separated on normal phases (often unmodified silica gel) using a rather low pressure (2-25 bar). Flash chromatography is therefore often referred to as low-pressure or medium-pressure liquid chromatography. Silica gels with a particle size distribution of 40 µm to 60 µm, but at least 25 µm, are mostly used. Therefore, the particle size is significantly higher and the resulting back pressure is lower than in HPLC.
At Analytics-Shop you will find a large selection of pre-packed columns in form of plastic cartridges with different packing materials, self-packing glass columns and other accessories for flash chromatography. Please feel free to contact our customer service if you have any questions.
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