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Precolumns (guard columns) and precolumn Cartridges for HPLC

Separating columns with modern solid phases are critical components of HPLC analysis. It is important to protect these valuable ingredients from contamination to ensure optimal and consistent separation. In order to prolong the "life" of your HPLC columns, it is advisable to use precolumns. Precolumns offer the advantage in HPLC that they also retain molecules which would form an irreversible bond with the column material. The precolumns should be exchanged regularly. A good indication of the time of the exchange is a gradual increase in the back pressure: For more information, see the care and maintenance of HPLC columns. We carry a wide range of solid phase and stainless steel cartridges for HPLC and UHPLC from the best manufacturers.


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Guard Columns

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  1. Chiral

    Chiral Technologies GUARD CARTRIDGE HOLDER

    sku: DA-IC00011
  2. Macherey-Nagel

    Column Protection System Guard Column Holder

    sku: MN-718966
  3. Thermo Fisher Scientific

    Acclaim SST Guard Cartridge Holder V-2

    sku: TF069580
  4. Thermo Fisher Scientific

    Acclaim Guard Kit (Holder and coupler) V-2

    sku: TF069707
  5. Thermo Fisher Scientific

    UNIGUARD Drop-in Holder, 3.0/2.1mm

    sku: TF852-00
  6. Altmann Analytik

    HPLC Guard Column Holder indirect, 10 x 3 mm

    sku: AAHI-01030
  7. Altmann Analytik

    HPLC Guard Column Holder indirect, 10 x 4 mm

    sku: AAHI-01040
  8. Thermo Fisher Scientific

    HPLC Guard Column Acclaim SEC-1000, 4,6 x 33mm, 7µm

    sku: TF082739
  9. Thermo Fisher Scientific

    HPLC guard cartridge 10x4mm 5µ Hypersil BDS C18 Guard 4/PAK

    sku: TF28105-014001
  10. Thermo Fisher Scientific

    10x2.1mm 5µ Hypercarb Guard 2/PAK

    sku: TF35005-012101
  11. Altmann Analytik

    HPLC Guard Column Holder indirect, 5 x 2 mm

    sku: AAHI-00520
  12. Altmann Analytik

    HPLC Guard Column Holder indirect, 5 x 4 mm

    sku: AAHI-00540
  13. ACE

    HPLC Guard Columnn Holder ACE , 2.1 mm

    sku: ACEQV-H0001
  14. Thermo Fisher Scientific

    UNIGUARD Drop-in Holder, 4.6/4.0mm

    sku: TF850-00
  15. Merck

    Guard Cartridge Holder Chromolith 5-4.6

    sku: MC1520320001
  16. Altmann Analytik

    HPLC Guard Column Holder indirect, 10 x 4,6 mm

    sku: AAHI-01046
  17. Whatman

    Guard Cartridge SAX 5/PAK

    sku: WH4641-0005
  18. Whatman

    Guard Cartridge SCX 5/PAK

    sku: WH4641-0007
  19. Whatman


    sku: WHP5C8-10C5-SK
  20. Thermo Fisher Scientific

    ProPac WCX-10G Guard Column (4 x 50 mm)

    sku: TF054994
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Consistent Resolution in RP Chromatography

It makes sense to ensure consistent resolution in reverse-phase (RP) chromatography by removing non-polar contaminants, particularly in diagnostics applications and food analysis. With our large selection of stainless steel guard columns and stationary phases, we can meet your needs for HPLC hardware and consumables.

Whenever consistent resolution and reproducibility are required, e.g. in samples from biological matrices, our customers can select from a wide variety of bonded solid phases. From food analysis to forensic toxicology, the routine for every chromatographic method is to use column guards to protect your investment and to ensure consistent operations at only a fraction of the cost for a new HPLC or UHPLC column.

When using HPLC guard columns to protect the columns, a column holder is required. The following diagrams show you the connection possibilities when you need a precolumn to an HPLC column (column connectors have to be ordered separately):

Wide Range of Manufacturers:

We offer all trusted brands, such as Agilent Technologies, Chiral, Grace, Macherey Nagel and Sielc. As a cost-effective alternative, we carry a large selection of our own high quality brand Altmann Analytik.