HPLC Column (R,R) Whelk-O1, 5 µm, 4.6 x 250 mm

The Whelk-O 1 Chiral Stationary Phase is based on 1-(3,5-Dinitrobenzamido)-1,2,3,4,-tetrahydrophenanthrene. This phase allows separation of nderivatized racemates from a number of families including amides, epoxides, esters, ureas, carbamates, ethers, aziridines, phosphonates, aldehydes, ketones, carboxylic acids, and alcohols. The Whelk-O 1 was originally designed for the separation of underivatized nonsteroidal anti-inflammatory drugs (NSAIDs). This π-electron acceptor/π-electron donor phase exhibits an extraordinary degree of generality, allowing resolution of a wide variety of underivatized racemates. This broad versatility observed on the Whelk-O 1 column, compares favorably with polysaccharide-derived chiral stationary phases. In addition, because of the Whelk-O 1’s covalent nature, this chiral phase is compatible with all commonly used mobile phases, including aqueous systems-a distinct advantage over polysaccharide-derived chiral stationary phases. Other advantages include column durability, excellent efficiency, elution order inversion allowing availability of both enantiomeric forms, and excellent preparative capacity.

WHELK-O 1 - The Original Immobilized Phase

• Excellent method development column with applicability to a wide
• range of compound classes
• Alternate selectivity to polysaccharide chiral stationary phases
• Covalently bonded for long term performance and broad mobile phase
• compatibility
• Broad range of particle sizes and dimensions for analytical to preparative
• scale separations
• High loading capacity for excellent scalability in preparative applications
• Choice of enantiomeric phases allows inversion of peak elution order
• Recognized as USP L102