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Using rotating baskets for tablet dissolution was the first official method and was adopted in 1970. This method is now known as Apparatus 1 or Method 1. The metallic drive shaft of the apparatus is connected to the cylindrical basket. The basket is positioned inside a vessel made of glass or other inert, transparent material. To keep the vessel contents at a constant temperature, they are placed inside a water bath or heating jacket. The rotating basket smoothly stirs the solution in the vessel. Dissolution baskets should be perfectly round, not deformed, with the correct and verified mesh size. The USP Method 1 requires a 40-mesh screen unless otherwise specified in the monograph. Other meshes can be used to solve individual problems.

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Dissolution Baskets and Shafts

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  1. QLA

    Japanese Pharmacopeia Basket Sinker, 316 SS (same dimensions as shown in USP)

    Regular Price: $221.93

    Special Price $210.83

    sku: QLCUSBSK-JP
  2. QLA

    40 Mesh (USP) Clip Style Basket for Erweka, 316 SS, Serialized

    Regular Price: $112.98

    Special Price $107.33

    sku: QLBSK040-EW
  3. QLA

    Spin ON/OFF Spring Clip Style Basket Shaft, 316 SS, Serialized

    Regular Price: $221.93

    Special Price $210.83

    sku: QLSPNBSK-01
  4. QLA

    10 Mesh Clip Style Basket for Agilent/VanKel, 316 SS, Serialized

    Regular Price: $141.23

    Special Price $134.17

    sku: QLBSK010-01
  5. QLA

    16.5 inch (420mm) Standard Push-On Style Basket Shaft for Distek 2100, 316 SS, Serialized

    Regular Price: $143.25

    Special Price $136.09

    sku: QLBSDRNG-16
  6. QLA

    19 inch (480mm) Standard Push-On Style Basket Shaft, 316 SS, Serialized

    Regular Price: $164.10

    Special Price $155.90

    sku: QLBSDRNG-19
  7. QLA

    8 Mesh Basket Sinker, 316 SS, 1.06 inch (26.9mm) L x .62 inch (15.7mm) W capacity

    Regular Price: $164.10

    Special Price $155.90

    sku: QLBSK008-01
  8. QLA

    8 Mesh Basket Sinker, 316 SS, .90 inch (22.9mm) L x .51 inch (12.9mm) W capacity

    Regular Price: $164.10

    Special Price $155.90

    sku: QLBSK008-JP
  9. QLA

    10 Mesh Standard Push-On Style Basket for Distek, 316 SS, Serialized

    Regular Price: $141.23

    Special Price $134.17

    sku: QLBSK010-DK
  10. QLA

    10 Mesh Evolution Series Basket for Distek, 316 SS, Serialized

    Regular Price: $141.23

    Special Price $134.17

    sku: QLBSK010-DKC
  11. QLA

    10 Mesh Clip Style Basket for Hanson, 316 SS, Serialized

    Regular Price: $141.23

    Special Price $134.17

    sku: QLBSK010-HR
  12. QLA

    10 Mesh Clip Style Basket for Pharmatest, 316 SS, Serialized

    Regular Price: $141.23

    Special Price $134.17

    sku: QLBSK010-PT
  13. QLA

    10 Mesh Clip Style Basket for Sotax, 316 SS, Serialized

    Regular Price: $141.23

    Special Price $134.17

    sku: QLBSK010-ST
  14. QLA

    20 Mesh Clip Style Basket for Agilent/VanKel, 316 SS, Serialized

    Regular Price: $141.23

    Special Price $134.17

    sku: QLBSK020-01
  15. QLA

    20 Mesh Standard Push-On Style Basket for Distek, 316 SS, Serialized

    Regular Price: $141.23

    Special Price $134.17

    sku: QLBSK020-DK
  16. QLA

    20 Mesh Evolution Style Basket for Distek, 316 SS, Serialized

    Regular Price: $141.23

    Special Price $134.17

    sku: QLBSK020-DKC
  17. QLA

    20 Mesh Clip Style Basket for Erweka, 316 SS, Serialized

    Regular Price: $141.23

    Special Price $134.17

    sku: QLBSK020-EW
  18. QLA

    20 Mesh Clip Style Basket for Hanson, 316 SS, Serialized

    Regular Price: $141.23

    Special Price $134.17

    sku: QLBSK020-HR
  19. QLA

    20 Mesh Clip Style Basket for Pharmatest, 316 SS, Serialized

    Regular Price: $141.23

    Special Price $134.17

    sku: QLBSK020-PT
  20. QLA

    20 Mesh Clip Style Basket for Sotax, 316 SS, Serialized

    Regular Price: $141.23

    Special Price $134.17

    sku: QLBSK020-ST
  21. QLA

    40 Mesh (USP) Clip Style Basket for Agilent/VanKel, 316 SS, Serialized

    Regular Price: $112.98

    Special Price $107.33

    sku: QLBSK040-01
  22. QLA

    40 Mesh (USP) Clip Style Basket for Caleva, 316 SS, Serialized

    Regular Price: $112.98

    Special Price $107.33

    sku: QLBSK040-CA
  23. QLA

    40 Mesh (USP) Evolution Style Basket for Distek, 316 SS, Serialized

    Regular Price: $112.98

    Special Price $107.33

    sku: QLBSK040-DKC
  24. QLA

    40 Mesh (USP) Clip Style Basket for Pharmatest, 316 SS, Serialized

    Regular Price: $112.98

    Special Price $107.33

    sku: QLBSK040-PT
  25. QLA

    40 Mesh (USP) Clip Style Basket for Sotax, 316 SS, Serialized

    Regular Price: $112.98

    Special Price $107.33

    sku: QLBSK040-ST
  26. QLA

    100 Mesh Clip Style Basket for Agilent/VanKel, 316 SS, Serialized

    Regular Price: $302.64

    Special Price $287.51

    sku: QLBSK100-01
  27. QLA

    150 Mesh Clip Style Basket for Agilent/VanKel, 316 SS, Serialized

    Regular Price: $503.05

    Special Price $477.90

    sku: QLBSK150-01
  28. QLA

    12 Position Basket Holder, Universal Compatibility

    Regular Price: $133.16

    Special Price $126.50

    sku: QLBSKHLD-12
  29. QLA

    Basket Adapter Hub for Distek Evolution Style Basket, 316 SS, Serialized

    Regular Price: $99.53

    Special Price $94.55

    sku: QLBSKHUB-DKC
  30. QLA

    40 Mesh Standard Push-On Style Basket for Distek, PTFE Coated over 316 SS, Serialized

    Regular Price: $262.28

    Special Price $249.17

    sku: QLBSKPTD-40
  31. QLA

    40 Mesh Clip Style Basket for Hanson, PTFE Coated over 316 SS, Serialized

    Regular Price: $262.28

    Special Price $249.17

    sku: QLBSKPTH-40
  32. QLA

    40 Mesh Clip Style Basket for Agilent/VanKel, PTFE Coated over 316 SS, Serialized

    Regular Price: $262.28

    Special Price $249.17

    sku: QLBSKPTV-40
  33. QLA

    14½ inch (370mm) Spring Clip Style Basket Shaft for V-Series, 316 SS, Serialized

    Regular Price: $160.06

    Special Price $152.06

    sku: QLBSKSHT-13
  34. QLA

    15 inch (380mm) Spring Clip Style Conical Basket Shaft for VanKel/Varian, 316 SS, Serialized

    Regular Price: $160.06

    Special Price $152.06

    sku: QLBSKSHT-15C
  35. QLA

    15 inch (380mm) O-Ring/Push-On Style Conical Basket Shaft for VanKel/Varian, 316 SS, Serialized

    Regular Price: $160.06

    Special Price $152.06

    sku: QLBSKSHT-15CO
  36. QLA

    19 inch (480mm) Spring Clip Style Conical Basket Shaft for VanKel/Varian, 316 SS, Serialized

    Regular Price: $189.65

    Special Price $180.17

    sku: QLBSKSHT-19C
  37. QLA

    19 inch (480mm) O-Ring/Push-On Style Conical Basket Shaft for VanKel/Varian, 316 SS, Serialized

    Regular Price: $189.65

    Special Price $180.17

    sku: QLBSKSHT-19CO
  38. QLA

    Suppository Basket for Agilent/VanKel, Plastic

    Regular Price: $168.13

    Special Price $159.72

    sku: QLBSKSUP-01
  39. QLA

    Suppository Basket for Caleva, Plastic

    Regular Price: $168.13

    Special Price $159.72

    sku: QLBSKSUP-CA
  40. QLA

    Suppository Basket for Distek Standard Push-On Style, Plastic

    Regular Price: $168.13

    Special Price $159.72

    sku: QLBSKSUP-DK
  41. QLA

    Suppository Basket for Erweka, Plastic

    Regular Price: $168.13

    Special Price $159.72

    sku: QLBSKSUP-EW
  42. QLA

    Suppository Basket for Hanson, Plastic

    Regular Price: $168.13

    Special Price $159.72

    sku: QLBSKSUP-HR
  43. QLA

    Suppository Basket for Pharmatest, Plastic

    Regular Price: $168.13

    Special Price $159.72

    sku: QLBSKSUP-PT
  44. QLA

    Suppository Basket for Sotax, Plastic

    Regular Price: $168.13

    Special Price $159.72

    sku: QLBSKSUP-ST
  45. QLA

    Clear Hinged Cover with Extra Hole for Stationary Basket for Distek Baths

    Regular Price: $113.66

    Special Price $107.98

    sku: QLCOVDHG-SB
  46. QLA

    Clear Hinged Cover with Extra Hole for Stationary Basket for Hanson SR8-Plus Baths

    Regular Price: $113.66

    Special Price $107.98

    sku: QLCOVHGH-SB
  47. QLA

    Disintegration Basket Assembly with 6 Plastic Tubes and 10 Mesh SS Screens for VanKel Testers

    Regular Price: $516.50

    Special Price $490.68

    sku: QLDISASY-P6
  48. QLA

    16 Position Paddle/Basket Shaft Holder

    Regular Price: $352.40

    Special Price $334.78

    sku: QLPADHLD-16A
  49. QLA

    16.5 inch (420mm) Detachable Threaded Shaft for Distek 2100, 316 SS, Serialized

    Regular Price: $156.70

    Special Price $148.87

    sku: QLSHFT16.5-DK
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Mesh Openings

The clogging of the mesh openings by particles or excipients or the random release of particles through the mesh to the bottom of the vessel are one of the biggest problems associated with the basket method. Suppository Baskets are from plastic, these baskets have vertical slots instead of mesh. This facilitates dissolution and prevents blocking and/or clogging of the mesh opening, particularly when oil-based suppositories are used. Sintered Mesh stainless steel baskets have welded joins at all the wire overlaps and adds considerable strength and longevity to the basket. Sintering is a strengthening process that compresses and heats the mesh under high pressures and temperatures. Baskets with a wide variety of mesh openings are available and if the disaggregated particle size is consistent, a variation of mesh size may solve some difficult dissolution problems.

Care and maintenance

The mesh of the dissolution baskets is easily bent and so they should only be handled by the rim. This also prevents oily deposits from fingers left on the mesh. Care should be exercised to ensure that baskets are clean prior to use and to ensure there is no contamination between tests. Correct storage of the baskets can extend their life. Baskets can easily be stored in the supplier’s case or using a specially designed basket holder.

Basket Shafts

As a part of Apparatus 1 the basket shaft is a metallic drive shaft which is attached to the cylindrical basket. They are available in two different versions, the spring-clip style and the O-ring style:

  • Spring Clips: the standard version of the dissolution basket is created so that the basket shaft is attached to it through the spring clips. As time passes, these clips can bend or corrode which can lead to excessive wobble of the dissolution basket on the shaft.
  • O-Ring: the clipless basket is attached to the shaft using an O-ring instead of the spring clips. While it can be argued that this design reduces wobble and is easier to use, the USP still specifies the use of clips and proof of equivalence may be required if a clipless alternative is to be used.

Care and Maintenance

Proper storage of the shafts is extremely important - a bent or corroded shaft fails to comply with USP regulations, so it is crucial not to store shafts on a table or loose in a drawer where damage or corrosion can occur. The right way to store is e.g. in a basket shaft or paddle holder as it can prevent occuring damage.