Use Thermo Scientific™ TurboFlow™ columns for automated online matrix purification of complex matrices analyzed on the Thermo Scientific™ Aria™, Transcend™ TLX, and Prelude™ LC-MS systems. The TurboFlow sample conditioning columns are placed before the analytical column and allow direct injection of complex matrices such as food, plasma, urine and other biological matrices into the mass spectrometry (MS) system without sample pretreatment. The patented TurboFlow column design retains interesting compounds for subsequent analysis, while complex matrices elute quickly and completely into the waste water.