5 ml Pestle, fluted, 2 pc/PAK

Please note that this product is "made to order". Therefore an order cannot be canceled or returned even if delivery times are longer!

Tissue grinders produce homogenates by a combination of shearing and compression actions. The tissue sample is progressively ground (sheared) into smaller pieces at the rounded end of the pestle as the spinning pestle is lowered into the tube. As the pestle is forced lower into the tube, the sample is displaced and forced between the straight outside wall of the pestle and the inside wall of the tube, compressing the tissue cells until they rupture. When the tube is pulled away from the pestle, a slight vacuum is created that pulls the sample back past the compression area, resulting in an additional homogenization stroke. The degree of homogenization is controlled by the clearance between the pestle’s and tube’s cylindrical section, the rotational speed of the pestle, and the number of compression strokes made.

The Potter-Elvehjem tissue grinder has rounded shape on the lower portion of the pestle where th sample is progressively ground smaller. Ground glass pestle versions are suited for connective tissues whereas PTFE pestle versions are used with softer tissues. These grinders are precisely constructed with completely interchangeable parts to allow easier cleaning or replacement of damaged tubes. They are designed for use in preparation of tissue homogenates and other similar applications. The PTFE pestle is for soft tissue such as brain or liver.