HPLC Column YMC-Pack ODS-AQ, 12nm, S-5 µm, 250 x 4.0 mm

The proprietary YMC derivatisation process creates the different selectivity of YMC-Pack ODS-AQ, where:

1. The activity of acidic unreacted silanols is reduced, allowing moderately basic compounds to be eluted with little or no peak tailing.

2. The balanced hydrophilic/lipophilic nature of the YMC- Pack ODS-AQ stationary phase leads to strong retentions of polar sample solutes even in aqueous eluents.

These properties of YMC-Pack ODS-AQ are beneficial for separations of polar organic compounds, which tend not to be retained or are unresolved when conventional C18 columns are used. Many conventional ODS packings lose their ability to retain polar compounds in these high aqueous content mobile phases as shown opposite. They appear less lipophilic with densely folded C18 chains. However, in similar mobile phases, YMC-Pack ODS-AQ maintains its brush-like C18 chain structure and its lipophilic properties and provides excellent retention of polar compounds.

Applications

YMC-Pack ODS-AQ is able to resolve compounds with minor differences in polarity from closely related chemical structures. As a result, YMC-Pack ODS-AQ is an excellent tool for the separation of drugs and corresponding metabolites, pesticides and degradation products, or peptides and protein digests etc. This capability of “polar recognition” opens up a broad application range for YMC-Pack ODS-AQ in life sciences and pharmacology. Genuine linear scale-up from analytical to large scale separations is easily achievable with YMC products such as YMC-Pack ODS-AQ, where particle sizes from 3 to 50 μm are available in large lot sizes up to several hundred kilograms, if needed. This, together with the outstanding selectivity of YMC-Pack ODS-AQ, make it an essential tool to enhance the productivity of large scale chromatographic processes.