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Nacalai HPLC Columns

As a supplier and producer of life science products, the Japanese company Nacalai Tesque is characterised by its high quality standards and strict compliance with ecological requirements. In addition to HPLC columns, we also offer HPLC guard columns and syringe filters from Nacalai Tesque.

The HPLC columns from Nacalai Tesque are available in various packing specifications such as Cosmocore, Cosmogel or Cosmosil, and differently packed with C18, C8, Amino, Cyano, Diol, Naphtyl-Ethyl and many more.

Detailed information can be found here.

Items 1-50 of 522

Product Image of HPLC Guard Column COSMOSIL RNA-SEC-2000, packed, 7.5 x 50 mm
HPLC Guard Column COSMOSIL RNA-SEC-2000, packed, 7.5 x 50 mm
Item number: CO-21096-91
Brand: Nacalai Tesque
$1,096.27
Product Image of HPLC Column COSMOSIL RNA-SEC-2000, packed, 7.5 x 300 mm
HPLC Column COSMOSIL RNA-SEC-2000, packed, 7.5 x 300 mm
Item number: CO-19381-11
Brand: Nacalai Tesque
$3,424.43
Product Image of HPLC Column COSMOSIL RNA-SEC-2000, packed, 4.6 x 250 mm
HPLC Column COSMOSIL RNA-SEC-2000, packed, 4.6 x 250 mm
Item number: CO-21095-01
Brand: Nacalai Tesque
$2,847.14
Product Image of HPLC Guard Column COSMOSIL RNA-SEC-1000, packed, 7.5 x 50 mm
HPLC Guard Column COSMOSIL RNA-SEC-1000, packed, 7.5 x 50 mm
Item number: CO-20785-91
Brand: Nacalai Tesque
$1,096.27
Product Image of HPLC Column COSMOSIL RNA-SEC-1000, packed, 7.5 x 300 mm
HPLC Column COSMOSIL RNA-SEC-1000, packed, 7.5 x 300 mm
Item number: CO-19380-21
Brand: Nacalai Tesque
$3,954.43
Product Image of HPLC Column COSMOSIL RNA-SEC-1000, packed, 4.6 x 250 mm
HPLC Column COSMOSIL RNA-SEC-1000, packed, 4.6 x 250 mm
Item number: CO-21088-01
Brand: Nacalai Tesque
$2,847.14
Product Image of HPLC Column COSMOSIL RNA-RP1, packed, 4.6 x 100 mm
HPLC Column COSMOSIL RNA-RP1, packed, 4.6 x 100 mm
Item number: CO-21079-21
Brand: Nacalai Tesque
$2,531.66
Product Image of HPLC Column COSMOSIL RNA-RP1, packed, 2 x 100 mm
HPLC Column COSMOSIL RNA-RP1, packed, 2 x 100 mm
Item number: CO-21078-31
Brand: Nacalai Tesque
$2,531.66
Product Image of HPLC Column COSMOSIL RNA-RP1, packed, 10 x 100 mm
HPLC Column COSMOSIL RNA-RP1, packed, 10 x 100 mm
Item number: CO-21080-81
Brand: Nacalai Tesque
$4,744.68
Product Image of HPLC Column COSMOSIL 5Diol-2000-II, packed, 2000Å, 5 µm, 7.5 x 300 mm
HPLC Column COSMOSIL 5Diol-2000-II, packed, 2000Å, 5 µm, 7.5 x 300 mm
Item number: CO-19976-31
Brand: Nacalai Tesque
$2,108.93
Product Image of HPLC Column COSMOSIL 3πNAP, packed, 120Å, 3 µm, 4.6 x 75 mm
HPLC Column COSMOSIL 3πNAP, packed, 120Å, 3 µm, 4.6 x 75 mm
Item number: CO-21523-81
Brand: Nacalai Tesque
$760.29
Product Image of HPLC Column COSMOSIL 3πNAP, packed, 120Å, 3 µm, 4.6 x 50 mm
HPLC Column COSMOSIL 3πNAP, packed, 120Å, 3 µm, 4.6 x 50 mm
Item number: CO-21522-91
Brand: Nacalai Tesque
$760.29
Product Image of HPLC Column COSMOSIL 3πNAP, packed, 120Å, 3 µm, 4.6 x 250 mm
HPLC Column COSMOSIL 3πNAP, packed, 120Å, 3 µm, 4.6 x 250 mm
Item number: CO-21526-51
Brand: Nacalai Tesque
$924.33
Product Image of HPLC Column COSMOSIL 3πNAP, packed, 120Å, 3 µm, 4.6 x 150 mm
HPLC Column COSMOSIL 3πNAP, packed, 120Å, 3 µm, 4.6 x 150 mm
Item number: CO-21525-61
Brand: Nacalai Tesque
$760.29
Product Image of HPLC Column COSMOSIL 3πNAP, packed, 120Å, 3 µm, 4.6 x 100 mm
HPLC Column COSMOSIL 3πNAP, packed, 120Å, 3 µm, 4.6 x 100 mm
Item number: CO-21524-71
Brand: Nacalai Tesque
$760.29
Product Image of HPLC Column COSMOSIL 3πNAP, packed, 120Å, 3 µm, 3 x 75 mm
HPLC Column COSMOSIL 3πNAP, packed, 120Å, 3 µm, 3 x 75 mm
Item number: CO-21513-11
Brand: Nacalai Tesque
$888.05
Product Image of HPLC Column COSMOSIL 3πNAP, packed, 120Å, 3 µm, 3 x 50 mm
HPLC Column COSMOSIL 3πNAP, packed, 120Å, 3 µm, 3 x 50 mm
Item number: CO-21509-81
Brand: Nacalai Tesque
$888.05
Product Image of HPLC Column COSMOSIL 3πNAP, packed, 120Å, 3 µm, 3 x 250 mm
HPLC Column COSMOSIL 3πNAP, packed, 120Å, 3 µm, 3 x 250 mm
Item number: CO-21521-01
Brand: Nacalai Tesque
$1,078.91
Product Image of HPLC Column COSMOSIL 3πNAP, packed, 120Å, 3 µm, 3 x 150 mm
HPLC Column COSMOSIL 3πNAP, packed, 120Å, 3 µm, 3 x 150 mm
Item number: CO-21520-11
Brand: Nacalai Tesque
$809.19
Product Image of HPLC Column COSMOSIL 3πNAP, packed, 120Å, 3 µm, 3 x 100 mm
HPLC Column COSMOSIL 3πNAP, packed, 120Å, 3 µm, 3 x 100 mm
Item number: CO-21514-01
Brand: Nacalai Tesque
$888.05
Product Image of HPLC Column COSMOSIL 3πNAP, packed, 120Å, 3 µm, 2 x 75 mm
HPLC Column COSMOSIL 3πNAP, packed, 120Å, 3 µm, 2 x 75 mm
Item number: CO-21496-51
Brand: Nacalai Tesque
$888.05
Product Image of HPLC Column COSMOSIL 3πNAP, packed, 120Å, 3 µm, 2 x 50 mm
HPLC Column COSMOSIL 3πNAP, packed, 120Å, 3 µm, 2 x 50 mm
Item number: CO-21495-61
Brand: Nacalai Tesque
$888.05
Product Image of HPLC Column COSMOSIL 3πNAP, packed, 120Å, 3 µm, 2 x 250 mm
HPLC Column COSMOSIL 3πNAP, packed, 120Å, 3 µm, 2 x 250 mm
Item number: CO-21500-71
Brand: Nacalai Tesque
$1,078.91
Product Image of HPLC Column COSMOSIL 3πNAP, packed, 120Å, 3 µm, 2 x 150 mm
HPLC Column COSMOSIL 3πNAP, packed, 120Å, 3 µm, 2 x 150 mm
Item number: CO-21499-21
Brand: Nacalai Tesque
$888.05
Product Image of HPLC Column COSMOSIL 3πNAP, packed, 120Å, 3 µm, 2 x 100 mm
HPLC Column COSMOSIL 3πNAP, packed, 120Å, 3 µm, 2 x 100 mm
Item number: CO-21497-41
Brand: Nacalai Tesque
$888.05
Product Image of HPLC Column COSMOSIL 3SL-II, 120 Å, 3 µm, 2 x 250 mm
HPLC Column COSMOSIL 3SL-II, 120 Å, 3 µm, 2 x 250 mm
Item number: CO-19400-51
Brand: Nacalai Tesque
$719.27
Product Image of HPLC Column COSMOSIL 3PBr, 120 Å, 3 µm, 3 x 75 mm
HPLC Column COSMOSIL 3PBr, 120 Å, 3 µm, 3 x 75 mm
Item number: CO-19350-11
Brand: Nacalai Tesque
$996.90
Product Image of HPLC Column COSMOSIL 3PBr, 120 Å, 3 µm, 3 x 50 mm
HPLC Column COSMOSIL 3PBr, 120 Å, 3 µm, 3 x 50 mm
Item number: CO-19349-51
Brand: Nacalai Tesque
$992.17
Product Image of HPLC Column COSMOSIL 3PBr, 120 Å, 3 µm, 3 x 100 mm
HPLC Column COSMOSIL 3PBr, 120 Å, 3 µm, 3 x 100 mm
Item number: CO-19351-01
Brand: Nacalai Tesque
$1,036.33
Product Image of HPLC Column COSMOSIL 3PBr, 120 Å, 3 µm, 2 x 75 mm
HPLC Column COSMOSIL 3PBr, 120 Å, 3 µm, 2 x 75 mm
Item number: CO-19346-81
Brand: Nacalai Tesque
$998.47
Product Image of HPLC Column COSMOSIL 3PBr, 120 Å, 3 µm, 2 x 100 mm
HPLC Column COSMOSIL 3PBr, 120 Å, 3 µm, 2 x 100 mm
Item number: CO-19347-71
Brand: Nacalai Tesque
$1,009.51
Product Image of HPLC Column COSMOSIL 3Cholester, 120 Å, 3 µm, 3 x 100 mm
HPLC Column COSMOSIL 3Cholester, 120 Å, 3 µm, 3 x 100 mm
Item number: CO-19196-51
Brand: Nacalai Tesque
$1,036.33
Product Image of HPLC Column COSMOSIL 3C18-AR-II, 120 Å, 3 µm, 4.6 x 250 mm
HPLC Column COSMOSIL 3C18-AR-II, 120 Å, 3 µm, 4.6 x 250 mm
Item number: CO-19391-81
Brand: Nacalai Tesque
$1,018.98
Product Image of COSMOSIL Buckyprep 120Å, 5 µm, 20.0 mm ID x 250 mm, price on request
COSMOSIL Buckyprep 120Å, 5 µm, 20.0 mm ID x 250 mm, price on request
Item number: CO-37982-81
Brand: Nacalai Tesque
$26,436.51
Product Image of HPLC column COSMOSIL PBr Packed column, 120Å, 5 µm, 20.0 mm ID x 50 mm
HPLC column COSMOSIL PBr Packed column, 120Å, 5 µm, 20.0 mm ID x 50 mm
Item number: CO-13257-31
Brand: Nacalai Tesque
$3,086.89
Product Image of HPLC column COSMOSIL PBr Packed column, 120Å, 5 µm, 10.0 mm ID x 150 mm
HPLC column COSMOSIL PBr Packed column, 120Å, 5 µm, 10.0 mm ID x 150 mm
Item number: CO-13255-51
Brand: Nacalai Tesque
$1,780.84
Product Image of COSMOSIL 2.5HILIC Packed column, 130Å, 2.5 µm, 3.0 mm ID x 75 mm
COSMOSIL 2.5HILIC Packed column, 130Å, 2.5 µm, 3.0 mm ID x 75 mm
Item number: CO-11772-31
Brand: Nacalai Tesque
$815.50
Product Image of COSMOSIL 2.5HILIC Packed column, 130Å, 2.5 µm, 2.0 mm ID x 75 mm
COSMOSIL 2.5HILIC Packed column, 130Å, 2.5 µm, 2.0 mm ID x 75 mm
Item number: CO-11768-01
Brand: Nacalai Tesque
$815.50
Product Image of COSMOSIL 3C18-EB Packed column, 120Å, 3 µm, 2.0 mm ID×75 mm
COSMOSIL 3C18-EB Packed column, 120Å, 3 µm, 2.0 mm ID×75 mm
Item number: CO-09795-11
Brand: Nacalai Tesque
$913.28
Product Image of HPLC Guard Cartridge COSMOSIL 3C18-PAQ, 120Å, 3µm, 2.0 x 10 mm, 2 pc/PAK
HPLC Guard Cartridge COSMOSIL 3C18-PAQ, 120Å, 3µm, 2.0 x 10 mm, 2 pc/PAK
Item number: CO-19874-74
Brand: Nacalai Tesque
$271.31
Product Image of HPLC Column COSMOSIL 3C18-PAQ packed, 120Å, 3 µm, 4.6 x 250 mm
HPLC Column COSMOSIL 3C18-PAQ packed, 120Å, 3 µm, 4.6 x 250 mm
Item number: CO-19873-71
Brand: Nacalai Tesque
$776.07
Product Image of HPLC Column COSMOSIL 3C18-PAQ packed, 120Å, 3 µm, 4.6 x 150 mm
HPLC Column COSMOSIL 3C18-PAQ packed, 120Å, 3 µm, 4.6 x 150 mm
Item number: CO-19872-81
Brand: Nacalai Tesque
$612.01
Product Image of HPLC Column COSMOSIL 3C18-PAQ packed, 120Å, 3 µm, 4.6 x 100 mm
HPLC Column COSMOSIL 3C18-PAQ packed, 120Å, 3 µm, 4.6 x 100 mm
Item number: CO-19871-91
Brand: Nacalai Tesque
$569.43
Product Image of HPLC Column COSMOSIL 3C18-PAQ packed, 120Å, 3 µm, 3.0 x 250 mm
HPLC Column COSMOSIL 3C18-PAQ packed, 120Å, 3 µm, 3.0 x 250 mm
Item number: CO-19789-91
Brand: Nacalai Tesque
$1,058.41
Product Image of HPLC Column COSMOSIL 3C18-PAQ packed, 120Å, 3 µm, 3.0 x 150 mm
HPLC Column COSMOSIL 3C18-PAQ packed, 120Å, 3 µm, 3.0 x 150 mm
Item number: CO-19788-01
Brand: Nacalai Tesque
$600.97
Product Image of HPLC Column COSMOSIL 3C18-PAQ packed, 120Å, 3 µm, 2.0 x 250 mm
HPLC Column COSMOSIL 3C18-PAQ packed, 120Å, 3 µm, 2.0 x 250 mm
Item number: CO-19781-71
Brand: Nacalai Tesque
$1,183.01
Product Image of HPLC Column COSMOSIL 3C18-PAQ packed, 120Å, 3 µm, 2.0 x 150 mm
HPLC Column COSMOSIL 3C18-PAQ packed, 120Å, 3 µm, 2.0 x 150 mm
Item number: CO-19780-81
Brand: Nacalai Tesque
$703.50
Product Image of HPLC Column COSMOSIL 3C18-PAQ packed, 120Å, 3 µm, 2.0 x 50 mm
HPLC Column COSMOSIL 3C18-PAQ packed, 120Å, 3 µm, 2.0 x 50 mm
Item number: CO-19773-81
Brand: Nacalai Tesque
$569.43
Product Image of HPLC Column COSMOSIL πNAP, 120 Å, 5 µm, 28 x 100 mm
HPLC Column COSMOSIL πNAP, 120 Å, 5 µm, 28 x 100 mm
Item number: CO-12563-41
Brand: Nacalai Tesque
$6,202.16
Product Image of HPLC Column COSMOSIL Cholester, 120 Å, 5 µm, 28 x 100 mm
HPLC Column COSMOSIL Cholester, 120 Å, 5 µm, 28 x 100 mm
Item number: CO-16592-41
Brand: Nacalai Tesque
$5,493.94

Items 1-50 of 522

Nacalai Tesque COSMOSIL HPLC-columns

The ‘Superb’ packing technique developed by Nacalai Tesque is used to produce the highly efficient HPLC columns. Totally porous silica particles are used, so that COSMOSIL columns have a higher chemical and mechanical stability as well as outstanding surface properties.

COSMOSIL ODS Columns

  • COSMOSIL 5C18-MS-II is a monomer-bound C18 phase with a new polar endcapping for better shielding of the surface resulting in extended pH stability and a significantly improved peak shape for basic compounds. It is a universal C18 phase and particularly effective for applications with low molecular organic compounds.
  • COSMOSIL 5C18-AR-II is a polymer-bound C18 phase that exhibits excellent stability and long life at low pH values. This phase is recommended for separation under acidic conditions and shows “shape selectivity" as opposed to monomer-bound C18 phases.
  • COSMOSIL 5C18-PAQ is a polar-modified C18 phase, specifically applied for the separation of polar compounds. It also shows excellent performance and reproducibility under 100% aqueous conditions.

COSMOSIL HPC-Columns – Special Selectivity

  • COSMOSIL Cholester is a reversed phase with a cholesteryl group. It exhibits a comparable hydrophobicity to traditional C18 phases, but also has enhanced stereoselectivity, especially in geometrical isomers and compounds with little structural differences.
  • COSMOSIL πNAP is a reversed phase with a naphthylethyl group that has stronger π-π interactions with unsaturated compounds than classical phenyl phases. In contrast to alkyl phases, the COSMOSIL πNAP offers a better separation of position isomers.
  • COSMOSIL PYE is a reversed phase with a 2- (1-pyrenyl) ethyl group. It shows a special retention characteristic based on several separation modes. For hydophobic and "charge transfer" interactions, this phase shows the strongest π-π interactions regarding the separation of structural isomers.
  • COSMOSIL HILIC is a special phase with a triazole group for Hydrophilic Interaction Chromatography (HILIC). Strongly polar compounds, which are not retained under reversed phase conditions, can be separated on this phase without any ion pair reagent. In addition, the phase shows a weak anion exchange mechanism with the positively charged stationary phase, so that even acidic compounds are well separated.
  • COSMOSIL Protein-R is a reversed phase specifically designed for the separation of proteins and peptides. The phase provides improved peak shapes through minimized tailing, higher recovery rates, and outstanding low pH stability compared to conventional Wide Pore 300Å C18 and C4 phases.
  • COSMOSIL Sugar-D is a novel phase, specifically designed for saccharide analysis. Compared to conventional aminopropyl phases, the COSMOSIL Sugar-D has an extended lifetime due to the novel "defense shield" protection, which simultaneously minimizes undesired adsorption of different saccharides.

Raw Material Silica Gel

COMSOSIL is based on ultra pure porous spherical silica gel (purity: 99.99% or higher). Low-purity silica gel contains metal impurity which may cause interference in the separation, especially for metal coordination compounds. 

Endcapping Treatment

The silanols (Si-OH groups) on the silica surface provided bonding site for stationary phases. However, part of the silanol groups remain un-capped as residual silanol groups even after the end-capping treatment, they cause peak tailing for basic compounds. COSMOSIL packing materials for reversed phase chromatography are of near-perfectly end-capped residual silanol groups.

Applications of the different HPLC Column Materials

Organic components

Separation Method Packing Material Properties
Reversed Phase 3C18-EB Excellent for standard analyses
Packing Material: Silica, 3 µm
C18-MS-II Multipurpose-C18 column
Monofunctional silylation of high-purity silica gel for almost any separation
C18-AR-II High acid resistance
Suitable for acidic samples and peptides
C18-PAQ Compatible with 100 % aqueous mobile phases
Suitable for hydrophilic solutions
Cholester Increased separation performance due to rigid cholesteryl structures
Comparable applications to C18
πNAP Stronger π-π interaction than with phenyl columns
PYE Offers the strongest π-π interactions of all columns
NPE Separation through π-π and dipole-dipole interactions
PBB-R Separation through the use of dispersion forces
C22-AR-II HPLC column with alkyl chains
C8-MS HPLC column with alkyl chains
C4-MS HPLC column with alkyl chains
TMS-MS HPLC column with alkyl chains
PE-MS π-π interaction between product and stationary phase
CN-MS High reproducibility using isocratic elutions
Normal Phase SL-II Suitable for preparative separations
Hydrophobe
Interactions		 HILIC Retains highly polar components that would be eluted at C18

Mono- and Oligosaccharides

Separation Method Packing Material Properties
Hydrophobe
Interactions		 Sugar-D Suitable for mono- and disaccharides
NH2-MS HPLC column that binds primary amines

Proteins

Separation Method Packing Material Properties
Reversed Phase Protein-R High separation performance and separation rate, acid-resistant
C18-AR-300 Reversed phase HPLC column with different pore sizes
C8-AR-300 Reversed phase HPLC column with different pore sizes
C4-AR-300 Reversed phase HPLC column with different pore sizes
Ph-AR-300 Reversed phase HPLC column with different pore sizes
Gel Permeation Diol-120-II Silica-based gel filtration
Separation of pore sizes: 5 000 - 100 000
Diol-300-II Silica-based gel filtration
Separation of the pore sizes: 10 000 - 700 000
Ion Exchange Type Q Anion exchange column for purifications
Preferred samples: acidic proteins, DNA
Type Q-N Anion exchange column for ultra-fast, precise analyses
Preferred samples: acidic proteins, DNA
Type S Cation exchange column for purifications
Preferred samples: basic proteins
Type SN Kationenaustausch Säule für ultraschnelle, präzise Analysen
Preferred samples: basic proteins
Type M Amphoteric ion exchange column for purifications
Preferred samples: any type of protein
Type M-N Amphotere Ionenaustauschsäule für präzise Analysen
Preferred samples: any type of protein
Hydrophobe
Interactions		 HIC Suitable for the separation of proteins, whereby enzyme activity and quaternary structure are greatly reduced

Fullerene

Packing Material Properties
Buckyprep Standard column for the separation of Fullerenes
Buckyprep-D Designed for the Separation of Fullerene derivatives
Buckyprep-M Designed für die Separation of Metallofullerenes
PBB Designed for the separation of C60, C70
PYE Separation of fullerenes and structural isomers
NPE Separation of fullerene derivatives

Carbon Nanotubes

Separation Method Packing Material Properties
Gel Permeation CNT Suited for the separation of Carbon nanotubes