The OligoWorks SPE 3 cc Cartridge Kit is designed for oligonucleotide bioanalysis. The kit contains 50, 3 cc Cartridges with 60 mg of OligoWorks WAX Sorbent/well, along with a RapiZyme Proteinase K Digestion Module, OligoWorks SPE Eluent, and a streamlined, automation friendly sample pretreatment and SPE protocol, for high oligonucleotide recoveries and enhanced LC-MS performance and productivity. The OligoWorks SPE WAX sorbent is a polymeric reversed-phase, weak anion exchange mixed-mode sorbent that is oligonucleotide tested and batch-selected for optimal oligonucleotide recovery.