The reference materials allow the user to better evaluate and benchmark their chromatography system before the analysis of critical material. These particular suitability standards are specially formulated mixtures including a void marker peak, a set of neutrals, or a combination of neutral, acidic and basic compounds. The compounds were vigorously evaluated and chosen because they provide the excellent benchmark, good peak shape in UV and are acceptable for use on a variety of columns. With these qualitative tools system readiness can be assessed on a regular basis. The health of the system can be monitored and the user can feel more confident about real sample results and lot-to-lot reproducibility.