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Chiral HPLC Columns
Daicel's chiral HPLC columns are the most widely used chiral chromatography products in the world. Because of their exceptionally high durability, high power capacity, versatility and excellent separation performance, they are used primarily in HPLC as well as supercritical fluid chromatography (SFC). In addition, chiral stationary phases (CSPs) have become the first choice for enatiomer analysis and separation of chiral substances.
The columns are available in a wide variety of configurations. To find the column you need more quickly and easily, use the filter options on the left or our HPLC column configurator.
Learn more about Daicel's column families.
Immobilised Chiralpak
Immobilised Chiralpak HPLC and SFC columns are packed with new Chiral Stationary Phases - consisting of a silica support onto which the polymeric chiral selector (polysaccharide derivatives) has been immobilised. Immobilisation of the polysaccharide derivatives on a matrix is an excellent approach to provide universal solvent compatibility on these highly selective Chiral Stationary Phases. This broadens the range of solvents to be used as mobile phases, thereby introducing new selectivity profiles, improved productivity and robustness in use.
| Phase | Particle Size in µm | Phase | Particle Size in µm |
|---|---|---|---|
| Chiralpak IA | 3 | 5 | Chiralpak IB SFC | 3.5 |
| Chiralpak IA SFC | 3.5 | Chiralpak IC | 3 | 5 |
| Chiralpak IB | 3 | 5 | Chiralpak IC SFC | 3.5 |
Coated Chiralpak
The predecessors to the new generation of immobilised columns, traditional CHIRALPAK and CHIRALCEL coated polysaccharide Chiral Stationary Phases are made with a spherical high quality silica support onto which the polymeric chiral selector (amylose or cellulose derivatives) is physically coated. Due to the coated nature of these chiral supports, solvents should be carefully selected.
| Phase | Particle Size in µm | Phase | Particle Size in µm |
|---|---|---|---|
| Chiralpak AD | 3 | 10 | Chiralpak AS | 3 | 10 |
| Chiralpak AD-H | 5 | Chiralpak AS-H | 5 |
| Chiralpak AZ | 3 | Chiralpak AY | 3 |
| Chiralpak AZ-H | 5 | Chiralpak AY-H | 5 |
Coated Chiralcel
The predecessors to the new generation of immobilised columns, traditional CHIRALPAK and CHIRALCEL coated polysaccharide Chiral Stationary Phases are made with a spherical high quality silica support onto which the polymeric chiral selector (amylose or cellulose derivatives) is physically coated. Due to the coated nature of these chiral supports, solvents should be carefully selected.
| Phase | Particle Size in µm | Phase | Particle Size in µm |
|---|---|---|---|
| Chiralcel OA | 10 | Chiralcel OF | 10 |
| Chiralcel OB | 10 | Chiralcel OG | 10 |
| Chiralcel OB-H | 5 | Chiralcel OJ | 3 | 10 |
| Chiralcel OC | 10 | Chiralcel OJ-H | 5 |
| Chiralcel OC-H | 5 | Chiralcel OK | 10 |
| Chiralcel OD | 3 | 10 | Chiralcel OZ | 3 |
| Chiralcel OD-H | 5 | Chiralcel OZ-H | 5 |
Reverse Phase Chiralpak
CHIRALPAK® -3R & [-RH] & CHIRALCEL® -R & [-RH] have been developed by DAICEL as the reverse phase versions of CHIRALPAK® AD-H, AS-H, AY-H, AZ-H & CHIRALCEL® OD-H, OJ-H, OZ-H (Columns which have the widest applicability in normal phase mode). They have the same coated chiral selector as found in the normal phase stationary phases, but are coated to a hydrophobic high quality silica support.
| Phase | Particle Size in µm | Phase | Particle Size in µm |
|---|---|---|---|
| Chiralpak AD-3R | 3 | Chiralpak AS-RH | 5 |
| Chiralpak AD-RH | 5 | Chiralpak AY-3R | 3 |
| Chiralpak AS-3R | 3 | Chiralpak AZ-3R | 2 |
Reverse Phase Chiralcel
CHIRALPAK® -3R & [-RH] & CHIRALCEL® -R & [-RH] have been developed by DAICEL as the reverse phase versions of CHIRALPAK® AD-H, AS-H, AY-H, AZ-H & CHIRALCEL® OD-H, OJ-H, OZ-H (Columns which have the widest applicability in normal phase mode). They have the same coated chiral selector as found in the normal phase stationary phases, but are coated to a hydrophobic high quality silica support.
| Phase | Particle Size in µm | Phase | Particle Size in µm |
|---|---|---|---|
| Chiralcel OD-3R | 3 | Chiralcel OJ-3R | 3 |
| Chiralcel OD-RH | 5 | Chiralcel OJ-RH | 5 |
| Chiralcel OD-R | 10 | Chiralcel OZ-3R | 3 |
Chiralpak
These two phases, QD-AX and QN-AX, are based on two complementary stereoisomeric quinine (qN) and quinidine (qD) derivatives. Due to their pseudo enantiomeric character they usually reveal reversed elution order for opposite enantiomers.
The Chiral Stationary Phases, WH and MA(+), in these columns are made of amino acids and its derivatives coated bonded to silica supports (with a particle size of 10 μm for WH and 3 μm for MA(+)). Since these columns are ligand-exchange type columns, the standard mobile phase to use is an aqueous solution of CuSO4 (0.1 to 2mM). These columns can tolerate organic modifiers such as Methanol and Acetonitrile according specifications in the instruction manual.
| Phase | Particle Size in µm | Phase | Particle Size in µm |
|---|---|---|---|
| Chiralpak QD-AX | 5 | Chiralpak WH | 10 |
| Chiralpak QN-AX | 5 | Chiralpak MA(+) | 3 |
Crownpak
These columns contain a chiral crown ether as a chiral selector, which is coated onto a 5 μm support. Acidic mobile phases such as Perchloric acid pH 1 to 2, are used to operate these columns under standard conditions. Note that to shorten the retention time of hydrophobic samples, the addition of Methanol (15% maximum v/v) has been shown to be effective. These columns are the reference columns for achieving amino acid separations, with the advantage the elution order of the enantiomers can be reversed when necessary (CR(-) column gives the reversed elution order compared to CR(+) column).
| Phase | Particle Size in µm | Phase | Particle Size in µm |
|---|---|---|---|
| Crownpak CR(+) | 5 | Crownpak CR(-) | 5 |
Chromtech Chiral
These protein-based columns are suitable for several types of compounds; basic compounds can be separated on both CHIRAL-AGP and CHIRAL-CBH, acidic and neutral compounds can be separated on both CHIRAL-AGP and CHIRAL-HSA. However, as CHIRAL-AGP is a column with an extremely broad applicability, this column should be chosen first, if the analyte has not been separated on any of the columns.
| Phase | Particle Size in µm | Phase | Particle Size in µm |
|---|---|---|---|
| Chromtech AGP | 5 | Chromtech HSA | 5 |
| Chromtech CBH | 5 |