InertSustain C18 employs a radically new type of silica, in which the surface of the silica is uniquely modifi ed, enabling precise control of the silica properties. InertSustain C18 inherits the advantages of all the current Inertsil HPLC columns (e.g., extremely low operating back pressure, superior inertness to typically any analytes, high effi ciency and compatibility with a wide range of solvents), but now can be used for wide pH analysis with consistent performance from column to column and lot to lot.