GL Sciences Inertsil CN-3, Cyanopropryl groups bonded to Silica gel with high density. And it is not only increase difference recognition of hydrophilicity, but also increase the durability. It is diffi cult to increase the both performance with other previous cyanopropryl columns. Inertsil CN-3 can be cleaned with 100 % aqueous solvent because non-specifi c adsorption of water effected with silanol base is prevented.